Capsules, tablets
As adjunctive (supplementary) treatment with other diuretics to increase excretion of sodium and water in the urine, while conserving potassium.
Amiloride promotes loss of sodium and water from the body by altering kidney enzymes that control urine production. Unlike other types of diuretics, amiloride belongs to a class that promotes excretion of excess water but does not deplete normal levels of potassium. In conjunction with thiazide or loop diuretics, amiloride reduces the overall fluid volume in the body and helps to control symptoms of heart disease, kidney disease, and liver disease.
In most cases, 5 mg a day, increased to 10 mg a day if necessary. Maximum dose is 20 mg a day. The drug is usually taken in one daily dose, preferably in the morning.
Two to four hours.
Up to 24 hours.
Amiloride can be taken with liquid or food to lessen stomach irritation. Avoid large quantities of high-potassium foods (see Food Interactions).
Store in a tightly sealed container away from heat and direct light.
Take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.
The decision to stop taking the drug should be made by your doctor.
No apparent problems.
No special precautions are warranted.
No special precautions are necessary.
No special precautions are necessary.
Animal studies have not shown birth defects. Adequate human studies have not been done. Consult your doctor about taking amiloride during pregnancy.
It is not known whether amiloride passes into breast milk. Consult your doctor about its use while nursing.
A small dose (0.625 mg per day) may be used in young children.
Rapid, irregular heartbeat, shortness of breath, nervousness, confusion, weakness, stupor.
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.
Tell your doctor if you are taking other drugs, especially ACE inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), digoxin, lithium, potassium supplements, another diuretic, cyclosporine, or tacrolimus.
Avoid consuming large servings of high-potassium foods, which include bananas, citrus fruits and juices, melons, prunes, (and most fruits in general), avocados, potatoes, nuts, baked beans, brussels sprouts, and skim milk.
Caution is advised when taking amiloride. Consult your doctor if you have any of the following: diabetes mellitus, gout, kidney stones, liver disease, or kidney disease.
View Interactions
