| |
|
|
Conditions & Diseases: A: A, Calcineurin |
A, Calcineurin
information on A, Calcineurin: Conditions & Diseases, alternative therapies, prescriptions and over-the-counter medicines, mental health treatment, recipes, diabetes treatment, allergy symptoms, women's health awareness, senior health, drug interactions, weight management issues, asthma treatment, health, disease, medicine, illness. Join our active support community now.
|
|
|
 |
|
|
|
A calcium- and calmodulin-binding protein present in highest concentrations in the central nervous system. Calcineurin is composed of two subunits. A catalytic subunit, calcineurin A, and a regulatory subunit, calcineurin B, with molecular weights of about 60 kD and 19 kD, respectively. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones, myosin light chain, and the regulatory subunit of cAMP-dependent protein kinase. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes in T-lymphocytes that act by inhibiting T-cell activation. EC 3.1.3.-.
|
|
|
